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KMID : 0381920120420030142
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Korean Journal of Microscopy
2012 Volume.42 No. 3 p.142 ~ p.146
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Distribution of Doublecortin Immunoreactivities in Developing Chick Retina
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Kim Young-Hwa
Sun Woong
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Abstract
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Doublecortin (DCX) is a microtuble-associated protein that is required for the migration of immature neuroblasts within the chick and mammalian brain. Although it is generally thought that DCX is expressed only in the neuroblasts, some mature neurons maintain DCX expression; for example, horizontal cells in adult rat retina. In this study, we demonstrate that retinal neural progenitors in the early embryonic stage of the chick also expressed DCX, as do developing ganglion cells and horizontal cells in later stages of development. These findings raise the possibility of a role for DCX in retinal neural
progenitors, before they become specialized into neuroblasts in the chick.
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KEYWORD
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Chick embryo, Doublecortin, Retina, Stem cells
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